Activin promotes follicular integrity and oogenesis in cultured pre-antral bovine follicles

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Activin promotes follicular integrity and oogenesis in cultured pre-antral bovine follicles.

The aim of this study was to determine the individual and combined effect of activin and follicle stimulating hormone (FSH) on somatic and germ cell development in cultured pre-antral follicles. Pre-antral bovine follicles (mean diameter 157 +/- 3, range 132-199 microm) were cultured for 8 days in serum-free medium in the presence of either 100 ng/ml of recombinant human activin A (rhAct A), 10...

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The fate of the follicular basal lamina during atresia was investigated using bovine follicles, in which different follicle phenotypes have been observed. These phenotypes include: healthy follicles with rounded basal granulosa cells with an aligned basal lamina or follicles with columnar basal granulosa cells with a basal lamina of many loops (loopy), and atretic follicles in which either the ...

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Capillary angiogenesis and degeneration in bovine ovarian antral follicles.

Angiogenesis and capillary degeneration are both evident during ovarian follicle growth. However, the characteristics and distribution of thecal capillary proliferative and degenerative structures have not been fully defined. Indeed, the role of thecal microvasculature changes in follicular atresia is still a matter of debate. The present study examined the distribution of thecal capillary chan...

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Acid and alkaline phosphatase in bovine antral follicles.

Acid and alkaline phosphatases were measured in the follicular fluid of 766 individual follicles from 96 cows. Follicles were obtained by bilateral ovariectomy or at slaughter from animals at various stages of the estrous cycle and pregnancy. Mean follicle size varied with the physiological state of the cow (P less than .0001). Acid phosphatase activity (U/microliters) varied inversely with fol...

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Bovine oocytes in early antral follicles grow in serum-free media: effect of hypoxanthine on follicular morphology and oocyte growth.

Some culture systems have been shown to support oocyte growth in mice, although there has been little success in applying these systems to other species. In the present study, we compared three culture conditions for growing bovine oocytes and examined the effect of hypoxanthine on oocyte growth. In the first experiment, early antral follicles, 0.4-0.7 mm in diameter were collected, and oocyte-...

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ژورنال

عنوان ژورنال: Molecular Human Reproduction

سال: 2010

ISSN: 1360-9947,1460-2407

DOI: 10.1093/molehr/gaq021